There are several repositories for Python language in GitHub and we are providing you with a list of top 30 among them.

1. Django

a high-level Python Web framework that encourages rapid development and clean, pragmatic design

2. Requests

HTTP for Humans – HTTP library, written in Python, for human beings

3. HTTPie

a command line HTTP client, a user-friendly cURL replacement.

4. flask

a microframework for Python based on Werkzeug, Jinja 2 and good intentions.

5. Tornado

a Python web framework and asynchronous networking library, originally developed at FriendFeed.

6. Ansible

This is a very simple IT orchestration engine with which you can easily deploy your applications and systems. A language can be automated that approaches plain English, using SSH, with no agents to install on remote systems.

7. Python Guide

a guidebook on Python best practices, written for Humans.

8. Sentry

Sentry is a realtime, platform-agnostic error logging and aggregation platform

9. Scrapy

Scrapy is a web crawling framework for Python which is also a fast high-level screen scraping.

10. YouCompleteMe

A code-completion engine for Vim

11. Youtube-dl

Small command-line program to download videos from YouTube.com and other video sites

12. Awesome-python

This is a list of some awesome Python frameworks, libraries and software. This list is inspired by awesome-php.

13. IPython

This is the official repository for IPython which contains things like the website, documentation builds, etc.

14. Mailpile

An experimental indexing and search engine for e-mail.

15. SShuttle

SShuttle is a transparent proxy server which works as a VPN and it doesn’t require admin. This program is compatible with Linux and MacOS and it also supports DNS tunneling.

16. boto

Boto is the Python interface to Amazon Web Services.

17. salt

This is the central system Infrastructure automation and configuration manager.

18. fabric

Fabric is a Python library and command-line tool for streamlining the use of SSH for application deployment or systems administration tasks.

19. Pelican

Pelican is a static site generator which provides support to Markdown and reST syntax. This generator is powered by Python.

20. python patterns

This is a collection of design patterns which gets implemented (by other people) using Python.

21. leGit

Git for Humans, Inspired by GitHub for Mac

22. pandas

Flexible and powerful data analysis / manipulation library for Python, providing labeled data structures similar to R data.frame objects, statistical functions, and much more

23. Huxley

Huxley is a test-like system for catching visual regressions in Web applications. It watches you browse, takes screenshots, and tells you when they change.

24. NewsBlur

NewsBlur is a personal news reader that brings people together to talk about the world. A new sound of an old instrument.

25. beets

This is a music library manager and MusicBrainz tagger.

26. Web.py

Web.py is a web framework for python that is very simple and powerful.

27. django-cms

The easy-to-use and developer-friendly CMS

28. GateOne

Gate One is an HTML5-powered terminal emulator and SSH client

29. Sick-Beard

This is a guide to PVR and it downloads and manages all your TV shows.

30. SublimeCodeIntel

It is a full-featured code intelligence and smart autocomplete engine.

Courtesy: Python Hackers